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The purpose of this systematic review was to compare corticosteroid injections with non-steroidal anti-inflammatory drug (NSAID) injections for musculoskeletal painin patients with active tuberculosis (TB) (Table ). Although the primary objective was to assess the safety of corticosteroid and non-steroidal anti-inflammatory drug (NSAID) injections, secondary objectives included assessment of the efficacy of corticosteroid and/or non-steroidal anti-inflammatory drug (NSAID) injections for treatment of musculoskeletal pain. The search was conducted in PubMed, CINAHL and PsycINFO from inception to December 31, 2013. The search strategy in CINAHL to identify relevant publications was designed for the purpose of providing higher quality data to assist in the design of meta-analyses of this intervention trial. The following searches were used: The objective of this meta-analysis of the efficacy of corticosteroid and non-steroidal anti-inflammatory drug (NSAID) injections for treatment of musculoskeletal pain in patients with active tuberculosis (TB) (Table ) was to provide an evidence-based recommendation for the use of corticosteroids and/or non-steroidal anti-inflammatory drugs (NSAIDs) for treatment of musculoskeletal pain in patients with active tuberculosis (TB). Sixty five participants were eligible for the analysis, which comprised patients with active TB (TB group) and controls matched for age (18-64; n=44; age range = 18-70 years) and sex. These included patients with active TB who had received corticosteroid and/or NSAID therapy at the end of the randomized treatment period. The patients' health status of the TB group at the start of the study was compared with the TB group at the end of the randomized treatment period. Inclusion criteria were: 1) active TB (TB group) with 1-year active therapy during the trial and who received corticosteroid treatment for at least 4 months and/or NSAID treatment for at least 1 month between the study periods; 2) a positive laboratory test for active TB (positive TB test is defined as positive TB culture in the serum or positive TB antigen in the sputum); 3) a positive physical examination according to a standardised checklist and the examination was performed by a certified healthcare professional (CCP); 4) no medication was started during the study period; and 5) no significant adverse events were reported as a result of the corticosteroid treatment (no TB group members or controls reported any major adverse events). Ten patients withdrew from the study, one from the control group after their Similar articles: